HEATSAFE directly tackles the need to adapt against climate change adverse effects in the whole Mediterranean area. The intensity of heatwaves is amplified in urban areas by factors such as the configuration of the city, the lack of vegetation or the materials of urbanized surfaces, so the strategy to mitigate their effects must be designed specifically for each territory. Sociodemographic conditions must also be considered, as significant correlation between exposure to extreme heat and socioeconomic vulnerability has been shown, leading to nearly double the mortality risk in some deprived districts. This local complex planning cannot be addressed without a clear methodology. HEATSAFE will address the most suitable ways to adapt these territories to these effects by developing key activities in Spain, Italy, Albania, Bulgaria and Greece, and with the aim of replicating project approach in the whole Mediterranean area.